Genetic Testing for Lactase Insufficiency
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چکیده
Background/Overview Genetic testing of adults with suspected lactase insufficiency is proposed as an alternative to current diagnostic practices. Studies have demonstrated a tight correlation between a single nucleotide polymorphism (SNP) -13910 C > T upstream of the gene coding for the enzyme lactase and lactase insufficiency in persons of European ancestry. Currently, two indirect tests of lactose digestion, the hydrogen breath test (HBT) and lactose tolerance blood test (LTT), are the most preferred diagnostic tests for confirmation of lactase insufficiency.
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Genetic Testing for Lactase Insufficiency
PLEASE NOTE: Contracts exclude from coverage, among other things, services or procedures that are considered investigational or cosmetic. Providers may bill members for services or procedures that are considered investigational or cosmetic. Providers are encouraged to inform members before rendering such services that the members are likely to be financially responsible for the cost of these se...
متن کاملGenetic Testing for Lactase Insufficiency
PLEASE NOTE: Contracts exclude from coverage, among other things, services or procedures that are considered investigational or cosmetic. Providers may bill members for services or procedures that are considered investigational or cosmetic. Providers are encouraged to inform members before rendering such services that the members are likely to be financially responsible for the cost of these se...
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Objective(s) Primary or adult type hypolactasia, the most common enzyme deficiency in the world, is due to reduced lactase activity in the intestinal cell after weaning. Lactase non-persistence is inherited as an autosomal recessive trait. A DNA variant, single nucleotide polymorphism C/T−13910 which is located on 13910 base pairs (bp) upstream of the lactase gene (LCT) at chromosome 2 has been...
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